XXI SIF Seminar

THURSDAY 20 SEPTEMBER

POSTER SESSION I | 14.30-16.00

P2X7R stimulation affects the growth and invasiveness of cancer stem cells derived from human glioblastoma multiforme
S. Ziberi (Chieti), M. Carluccio, A. D’Orazio, L. Ricci-Vitiani, R. Pallini, F. Caciagli, R. Ciccarelli
P1
Effects of digitoxin on cell migration in ovarian cancer inflammatory microenvironment
C. Boscaro (Padua), A. Trenti, S. Tedesco, A. Cignarella, C. Bolego, L. Trevisi
P2
The role of hypoxia in glioblastoma cell models
A. Graziosi (Bologna), G. Sita, F. Morroni, P. Hrelia
P3
Precision therapy for pediatric BCR-ABL-like acute lymphoblastic leukemia with activation of the ABL pathway: development of an in vitro system for diagnosis and clinical monitoring
O. Montecchini (Trieste), R. Franca, C. Sorio, M. Vezzalini, M. Lucafò, M. Rabusin, G. Decorti, G. Stocco
P4
[Methyl-3H] thymidine incorporation assay for the prediction of the correct drug association in patients with chronic kidney disease who need kidney transplantation
D. Selvestrel (Trieste), M. Lucafò, S. Granata, G. Zaza, G. Decorti, G. Stocco
P5
Ultrasensitive surface-enhanced Raman spectroscopy as diagnostic tool for circulating microRNA 122 detection in hepatocellular carcinoma patients
A. Di Silvestre (Trieste), E. Mitri, D. Pascut, V. Sergo, S. L. Crocè, M. Rossano Buonocore, C. Tiribelli, A. Bonifacio
P6
TLR-4/Wnt modulation as new therapeutic strategy in the treatment of glioblastomas
G. Casili (Messina), M. Caffo, M. Campolo, V. Barresi, G. Caruso, S. M. Cardali, M. Lanza, R. Mallamace, A. Filippone, A. Conti, A. Germanò, S. Cuzzocrea, E. Esposito
P7
Glucocorticoid receptor alternative splicing regulation and effects in triple-negative breast cancers cells
M. Ronfani (Pavia), E. Buoso, M. Galasso, S. Gesa, L. Setti, M. Racchi
P8
Zoledronic acid regulates osteoclast/osteoblast homeostasis: possible involvement of ionic channels on cell proliferation
R. Scala (Bari), F. Maqoud, A. Scilimati, D. Tricarico
P9
The level of activating EGFR mutations in circulating tumor DNA is a biomarker of response to osimertinib
E. Rofi (Pisa), M. Del Re, P. Bordi, G. Restante, S. Valleggi, R. Minari, S. Crucitta, E. Arrigoni, A. Chella, R. Morganti, M. Tiseo, I. Petrini, R. Danesi
P10
Characterization of VEGF receptors in rat adipose stem cells
A. Vona (Florence), L. Di Cesare Mannelli, L. Micheli, E. Lucarini, E. Trallori, C. Ghelardini, P. Failli
P11
Possible involvement of Kv7 channels in human malignant hyperthermia
O. L. Manzo (Naples), V. Vellecco, A. Martelli, G. Cirino, M. Bucci, A. Mancini, V. Citi, M. Vallifuoco, V. Calderone
P12
Atheroprotective activity of tofacitinib through macrophage cholesterol homeostasis modulation
C. Marchi (Parma), M. P. Adorni, F. Bernini, N. Ronda
P13
Vasorelaxing activity of stilbenoid and phenanthrene derivatives from Brasiliorchis porphyrostele Rchb.f. (Orchidaceae): involvement of smooth muscle CaV1.2 and KV channels
M. Durante (Siena), W. Waratchareeyakul, A. Rocco, D. De Feo, C. Sandroni, F. D’Ortona, E. Maione, S. L. Schwikkard, W. Knirsch, D. A. Mulholland, F. Fusi
P14
Lipid abnormalities in patients on statin therapy: the TREAT study
M. Gazzotti (Milan), M. Casula, E. Olmastroni, A. L. Catapano
P15
Proprotein convertase subtilisin-kexin TYPE-9 (PCSK9) inhibitors and triglyceride-rich lipoprotein metabolism: meta-analyses of randomized trials
E. Olmastroni (Milan), M. Casula, A. Baragetti, A. L. Catapano
P16
Leaf extract of Morus alba, active component of LopiGLIK®, reduces the expression of PCSK9 in HepG2 cell line
M. G. Lupo (Padua), A. Corsini, N. Ferri
P17
P18 Ranolazine attenuates adverse myocardial remodeling, lung capillaries and endothelial dysfunction in a model of heart failure with preserved ejection fraction
L. P. Ciuffreda (Naples), A. De Angelis, D. Cappetta, G. Esposito, E. Piegari, K. Urbanek, F. Rossi, L. Berrino
P18
Effects of a new compound containing Palmitoylethanolamide and Baicalein in myocardial ischaemia/reperfusion injury in vivo
R. D’Amico (Messina), R. Fusco, E. Gugliandolo, M. Cordaro, R. Siracusa, D. Impellizzeri, A. F. Peritore, R. Crupi, S. Cuzzocrea, R. Di Paola
P19
Cross-talk between endogenous H2S and NO accounts for vascular protective activity of the metal-nonoate Zn(PipNONO)Cl
I. Hyseni (Siena), M. Monti, L. Casella, L. Morbidelli
P20
Intravitreal Injections of Melanocortin Receptor 1, 5 Agonists Prevents Neovascularization in a VEGF165 Mouse Model of Retinopathy
M. C. Trotta (Naples), R. Maisto, S. Rossi, C. Gesualdo, D. Siniscalco, F. Ferraraccio, J. M. Barcia, F. Simonelli, C. Di Filippo, M. D’Amico
P21
GILZ (Glucocorticoid Induced Leucin Zipper) is a novel regulator of hematopoietic stem cell function
S. Flamini (Perugia), T. Frammartino, A. Gagliardi, S. Bruscoli, O. Bereshchenko, C. Riccardi
P22
Atomic force microscopy as innovative tool for therapeutic drug monitoring in pediatric inflammatory bowel disease
D. Curci (Trieste), M. Lucafò, L. Casalis, P. Parisse, G. Stocco, G. Decorti
P23
Effect of prolonged lurasidone treatment on chronic mild stressinduced alterations: a role for glucocorticoid receptor
P. Brivio (Milan), F. Calabrese, B. Sbrini, M. Papp, M. A. Riva
P24
Changes of gene and protein expression of skeletal muscle ClC1 channel during lifespan: toward the development of new phenotype and age specific personalized medicine
E. Conte (Bari), A. Fonzino, A. Cibelli, S. Pierno, G. P. Nicchia, A. De Luca, G. M. Camerino
P25
Functional alteration of gastrointestinal tract in a mouse model of diet induced-obesity
F. Garelli (Padua), A. Nericcio, S. Cerantola, I. Marsilio, M. C. Giron, R. Colucci
P26
Role of high sugar exposure in metabolic inflammation: a comparative in vivo study on fructose and its epimer D-tagatose in both liquid and solid formulations
D. Collotta (Turin), L. Lucarini, F. Chiazza, A. Cento, M. Durante, S. Sgambellone, M. Aragno, R. Mastrocola, E. Masini, M. Collino
P27
Effects of JMV2959 and EP80317, two ghrelin antagonist, in a in vivo model of obesity
L. Rizzi (Milan), L. Molteni, E. Bresciani, R. Meanti, V. Locatelli, A. Torsello
P28
Insulin analogue glargine 300 U/mL and 100 U/mL: the same active principle for two different drugs
J. Angelini (Milan), M. Morina, F. Scaglione
P29
Impact of e-cig vaping personalization on antioxidant defense: a multidisciplinary approach
S. Cirillo (Bologna), F. Vivarelli, V. Cardenia, M. T. Rodriguez-Estrada, M. Paolini, D. Canistro
P30
Intestinal EphB/EphrinB mRNA levels and expression in a murine model of Crohn’s disease
S. Palese (Parma), A. Grandi, I. Zini, V. Vivo, F. Marchesani, S. Bruno, M. Tognolini, R. Castelli, S. Bertoni, E. Barocelli
P31
miR-331-3p is involved in glucocorticoid resistance reversion by rapamycin through suppression of the JNK signalling pathway
M. Lucafò (Trieste), D. Sicari, A. Chicco, A. Di Silvestre, L. Collavin, G. Decorti, G. Stocco
P32
Identification of a cellular model to investigate on the possible molecular mechanisms by which thalidomide can regulate TNF-α expression
L. Pugnetti (Trieste), M. Lucafò, D. Curci, M. Bramuzzo, G. Stocco, G. Decorti
P33
New insights on the role of store-operated calcium-entry in rare genetic diseases
C. Cordero Sanchez (Novara), B. Riva, A. Griglio, M. Serafini, M. Garibaldi, E. Bertini, G. Tasca, T. Pirali, A. A. Genazzani
P34
Treating Myotonia Congenita with pharmacological chaperone: niflumic acid as trafficking corrector of ClC-1 chloride channel mutants
C. Altamura (Bari), P. Imbrici, D. Sahbani, S. Lucchiari, G. P. Comi, M. Lo Monaco, E. Ivanova, M. R. Carratù, D. Conte Camerino, J. F. Desaphy
P35
Novel and rare variants in the DPYD gene possibly associated to 5-fluorouracil and capecitabine toxicity: a case series
R. Talotta (Milan), F. Rucci, M. S. Cigoli, U. Cavallari, S. Siena, M. Cantore, G. Canti, F. Scaglione
P36
Role of miR-193a mimics as new potential therapeutic agents in cutaneous melanoma
B. Polini (Pisa), S. Carpi, E. Ylösmäki, L. Ylösmäki, S. Feola, V. Cerullo, A. Romanini, P. Nieri
P37
Abacavir pharmacogenetics: screening of the allele variant HLA-B*57.01 to prevent hypersensitivity reactions
V. Canoro, C. Sellitto (Salerno), T. Iannaccone, R. Vitolo, M. Langella, C. Selleri, V. Manzo, B. Charlier, F. Iannello, V. Izzo, V. Conti, A. Filippelli
P38

FRIDAY 21 SEPTEMBER

POSTER SESSION II | 14.00-15.30

Evaluation of the pharmacological and toxicological profile of a new topical minoxidil formulation in male rat: involvement of the ATP-sensitive potassium channel (K+ATP) in hair growth and cell proliferation
F. Maqoud (Bari), R. Scala, A. Lopedota, D. Tricarico
P39
A fluorescence-based assay to evaluate the activity of Kv7.2/Kv7.3 channel modulators
P. Nappi (Naples), F. Miceli, A. Lauritano, P. Scuderi, L. Galietta, C. Ostacolo, P. Campiglia, M. Taglialatela
P40
Pharmacological profile of the neuropeptide S receptor: dynamic mass redistribution studies
F. Ferrari (Ferrara), C. Ruzza, R. Guerrini, E. Marzola, D. Preti, R. K. Reinscheid, G. Calò
P41
Dextran sulfate sodium-induced colitis and behavior disorders in mice
O. A. Parisi (Naples), E. Pagano, M. Iannotta, C. Cristiano, A. Calignano, F. Guida, A. A. Izzo, F. Borrelli
P42
RGS4 inhibition potentiates the antidyskinetic effect of NOP receptor agonism
C. A. Pisanò (Ferrara), D. Mercatelli, R. R. Neubig, M. Morari
P43
Pharmacological characterization of the intracellular signalling pathway activated by TLQP-21 in CHO cells
L. Molteni (Milan), L. Rizzi, E. Bresciani, R. Meanti, A. Torsello, V. Locatelli
P44
Targeting A3 adenosine receptor for post-inflammatory visceral pain management
E. Lucarini (Florence), L. Di Cesare Mannelli, L. Micheli, C. Parisio, E. Coppi, K. A. Jacobson, D. Salvemini, C. Ghelardini
P45
Procognitive effects of an omega-3 Fatty Acid-Vitamin A enriched diet or of Oleoylethanolamide on the cognitive impairment induced by chronic stress. Role of the brain histaminergic system
B. Rani (Florence), G. Provensi, S. D. Schmidt, P. Blandina, M. B. Passani, A. Costa
P46
Vulnerability and resilience to chronic stress exposure: basal changes and altered responsiveness to a dexamethasone challenge
V. Begni (Milan), G. Longoni, M. Papp, M. A. Riva
P47
A drug repositioning strategy for novel pharmacological approaches in Down syndrome
M. E. Salvalai (Novara), V. Bortolotto, E. Xia, R. Bartesaghi, M. Grilli
P48
Pharmacological and complementary (meditation/mindfulness) interventions to slow down biological aging: an overview
M. Campisi (Padua), S. Pavanello
P49
Inhibition of 5alpha-reductase reduces L-DOPA-induced dyskinesia via normalization of dopamine d1-receptor signaling pathway
S. Fanni (Cagliari), F. Rossi, F. Traccis, P. Saba, S. Scheggi, P. Devoto, M. Bortolato, M. Carta, R. Frau
P50
Unravelling the role of carbonic anhydrases on fear memory extinction
G. Provensi (Florence), S. D. Schmidt, B. Rani, A. Costa, F. Carta, M. B. Passani, I. Izquierdo, C. T. Supuran, P. Blandina
P51
The selective inhibition of FAAH ameliorates cognitive decline, depressive-like symptoms and neuropathological alterations in a murine model of Alzheimer’s disease
S. Calcagnini (Rome), G. Bedse, M. Lavecchia, A. Caruso, S. Scaccianoce, M. De Ceglia, C. A. Gallelli, A. Romano, T. Cassano, S. Gaetani
P52
Effects of subdiaphragmatic deafferentation on oleoylethanolamideinduced Fos expression in the brain
M. De Ceglia (Rome), J. B. Koczwara, C. A. Gallelli, E. K. Azari, M. Arnold, A. Romano, S. Gaetani
P53
Activation of A2A receptor by PDRN reduces neuronal damage and stimulates Wnt/β-catenin driven neurogenesis in spinal cord injury
N. Irrera (Messina), F. Mannino, G. Pallio, F. Squadrito, D. Altavilla, A. Bitto
P54
Amyloid cascade and actin cytoskeleton remodelling: an inner dialogue in the frame of Alzheimer Disease
S. Pelucchi (Milan), L. Vandermeulen, S. Musardo, D. Lim, M. Passafaro, M. Mikhaylova, D. Di Marino, F. Gardoni, M. Di Luca, E. Marcello
P55
2-Pentadecyl-2-Oxazoline reduces neuroinflammatory environment in the MPTP model of Parkinson Disease
M. Cordaro (Messina), R. Siracusa, R. Crupi, D. Impellizzeri, A. F. Peritore, R. D’Amico, E. Gugliandolo, R. Di Paola, S. Cuzzocrea
P56
Rabphilin 3A modulates structural and functional synaptic plasticity through interaction with GluN2A/PSD-95 complex
L. Franchini (Milan), J. Stanic, S. Musardo, E. Zianni, M. Mellone, C. Racca, M. Di Luca, C. Bellone, F. Gardoni
P57
C-Jun N-terminal kinase 1 regulates adult hippocampal neurogenesis and controls anxiety and depressive behaviour
H. Mohammad, F. Marchisella (Milan), S. Ortega-Martinez, P. Hollos, K. Eerola, E. Komulainen, N. Kulesskaya, E. Freemantle, V. Fagerholm, E. Savantous, H. Rauvala, B. Peterson, H. P. Van Praag, E. Coffey
P58
Dopamine D3 receptor-dependent expression of alpha6 GABAA receptor subunit counteracts voluntary alcohol intake
G. M. Leggio, R. Di Marco, M. D’Ascenzo, S. A. Torrisi, F. Geraci (Catania), G. Lavanco, K. Dahl, G. Giurdanella, A. Castorina, T. Aitta- Aho, G. Aceto, C. Bucolo, C. Grassi, E. R. Korpi, F. Drago, S. Salomone
P59
Possible relationship between the epigenetic regulation of oxytocin receptor in OCD and alcoholic subjects
F. Bellia (Teramo), B. Dell’Osso, M. Vismara, D. Galimberti, M. Maccarrone, V. Vukojevic, L. Terenius, C. D’Addario
P60
Oxytocin and the development of the olfactory bulb: potential early-life predisposition to altered sociality
V. Gigliucci (Milan), B. Chini
P61
Functional investigation of the reward striatal system in the valproic acid model of autism
D. Iezzi (Florence), C. Carbone, A. Ilari, M. Urru, G. Mannaioni, A. Masi
P62
The NOP receptor antagonist LY2817412 decreases alcohol drinking in male and female Marchigian Sardinian Alcohol-Preferring (msP) rats
A. M. Borruto (Camerino), Y. Fotio, S. Stopponi, N. Cannella, R. Ciccocioppo
P63
The mixed opioid receptor agonist Cebranopadol reduces heroinseeking behaviors in the rat
A. Ilari (Camerino), Q. Shen, N. Cannella, R. Ciccocioppo
P64
Sodium butyrate exerts neuroprotective effects in spinal cord injury
M. Lanza (Messina), M. Campolo, G. Casili, A. Filippone, S. Cuzzocrea, E. Esposito
P65
Neuroprotective effect of Artesunate in experimental model of traumatic brain injury
E. Gugliandolo (Messina), R. D’Amico, M. Cordaro, R. Fusco, R. Siracusa, R. Crupi, D. Impellizzeri, S. Cuzzocrea, R. Di Paola
P66
PKC-dependent phosphorylation modulates RNF10 activity in hippocampal neurons
N. Carrano (Milan), T. Samaddar, E. Marcello, M. Di Luca, F. Gardoni
P67
Prokineticin system’s antagonism: implications in a mouse model of chemotherapy-induced peripheral neuropathy
G. Moschetti (Milan), G. Amodeo, D. Maftei, T. Kalpachidou, R. Lattanzi, M. Kress, P. Sacerdote, S. Franchi
P68
The protective effect of sodium propionate: antioxidant, antiinflammatory and neuroprotective properties
A. Filippone (Messina), M. Campolo, G. Casili, M. Lanza, I. Paterniti, S. Cuzzocrea, E. Esposito
P69
N-Palmitoylethanolamine-oxazoline Protects Against Neuroinflammatory Injury Induced by Middle Cerebral Artery Occlusion
A. F. Peritore (Messina), R. Fusco, M. Cordaro, R. D’Amico, E. Gugliandolo, R. Siracusa, R. Crupi, D. Impellizzeri, S. Cuzzocrea, R. Di Paola
P70
Co-ultraPEALut: role in preclinical delirium manifestations
R. Siracusa (Messina), R. Crupi, M. Cordaro, D. Impellizzeri, R. Di Paola, S. Cuzzocrea
P71
Cerebral gene expression alterations in the α-galactosidase A deficient mouse: likely correlations with the neurological hallmarks of Fabry disease
L. Rullo (Bologna), F. F. Caputi, M. Caprini, P. Romualdi, S. Candeletti
P72
The Hexane Fraction of Bursera microphylla A Gray Induces p21- Mediated Antiproliferative and Proapoptotic Effects in Human Cancer–Derived Cell Lines
S. Adorisio (Perugia), A. Fierabracci, G. Gigliarelli, I. Muscari, L. Cannarile, A. M. Liberati, M. C. Marcotullio, C. Riccardi, M. Curini, R. E. Robles Zepeda, D. V. Delfino
P73
The phytoestrogen Genistein stimulates bone remodelling through Wnt/β-catenin pathway in an in vitro model of osteoporosis
F. Mannino (Messina), N. Irrera, G. Pallio, F. Squadrito, D. Altavilla, A. Bitto
P74
Prevalence, Determinants and Patterns of Use of Medicinal Plants among People Living with HIV in Dschang, Cameroon
A. Mabou Tagne (Varese), M. Cosentino, F. Marino, P. C. Biapa Nya, A. Tiotsia Tsapi, A. K. Edingue Essoh, G. Pembouong, M. A. Ngouadjeu Ngnintedem, F. Marino, M. Cosentino
P75